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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities    
Net loss $ (44,724) $ (45,017)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 2,809 2,903
Stock-based compensation 4,491 3,799
Changes in operating assets and liabilities:    
Accounts receivable 938 23,468
Prepaid expenses (1,345) (1,902)
Other assets 695 (2,079)
Accounts payable (2,286) (2,531)
Accrued expenses (2,118) (4,297)
Lease liabilities (869) 1,086
Deferred revenue (2,248) (5,430)
Other liabilities 515 0
Net cash used in operating activities (44,142) (30,000)
Cash flows from investing activities    
Purchases of marketable securities (61,186) (81,597)
Proceeds from sale and maturities of marketable securities 73,003 12,780
Purchases of property and equipment (1,253) (1,675)
Net cash provided by (used in) investing activities 10,564 (70,492)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 0 118,657
Proceeds from stock option exercises and ESPP purchases 162 348
Net cash provided by financing activities 162 119,005
Net change in cash and cash equivalents (33,416) 18,513
Cash and cash equivalents at beginning of period 126,472 220,128
Cash and cash equivalents at end of period 93,056 238,641
Supplemental Cash Flow Information [Abstract]    
Right-of-use assets modified in exchange for operating lease obligations $ 0 $ 1,988