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Stock-Based Compensation - Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2019
Shares      
Shares, Outstanding, Beginning Balance (in shares) 6,706,994    
Shares, Granted (in shares) 1,816,277    
Shares, Exercised (in shares) (448,732)    
Shares, Forfeited or expired (in shares) (735,322)    
Shares, Outstanding, Ending Balance (in shares) 7,339,217   6,706,994
Shares, Exercisable (in shares) 4,407,713    
Shares, Vested and expected to vest (in shares) 7,027,237    
Weighted- Average Exercise Price      
Weighted- Average Exercise Price, Outstanding, Beginning Balance (in dollars per share) $ 22.33    
Weighted- Average Exercise Price, Granted (in dollars per share) 14.97    
Weighted- Average Exercise Price, Exercised (in dollars per share) 9.93    
Weighted- Average Exercise Price, Forfeited or expired (in dollars per share) (20.78)    
Weighted- Average Exercise Price, Outstanding, Ending Balance (in dollars per share) 21.42   $ 22.33
Weighted- Average Exercise Price, Exercisable (in dollars per share) 23.03    
Weighted- Average Exercise Price, Vested and expected to vest (in dollars per share) $ 21.50    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]      
Weighted- Average Remaining Contractual Term, Outstanding 7 years   6 years 10 months 24 days
Weighted- Average Remaining Contractual Term, Exercisable 5 years 10 months 24 days    
Weighted- Average Remaining Contractual Term, Vested and expected to vest 7 years    
Aggregate Intrinsic Value, Outstanding, Ending Balance $ 39,014    
Aggregate Intrinsic Value, Exercisable 18,806    
Aggregate Intrinsic Value, Vested and expected to vest $ 36,973    
Weighted-average grant-date fair value of options granted (in dollars per share) $ 10.50 $ 14.33  
Intrinsic value of options exercised $ 3,900 $ 2,800  
Cash received for options exercised 4,500 700  
Fair value of shares vested 12,400 $ 12,800  
Unrecognized compensation expense related to non-vested stock-options, net of related forfeiture estimates $ 31,700    
Unrecognized compensation expense recognition period 2 years 6 months