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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating activities |  |  |
Net loss | $ (129,739) | $ (151,811) | $ (171,453)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization expense | 11,957 | 12,306 | 9,160
Amortization of premiums and discounts on marketable securities | (260) | (1,461) | (881)
Share-based compensation | 20,676 | 19,571 | 16,520
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (10,337) | 16,839 | (15,941)
Prepaid expenses | (5,697) | (4,878) | (3,255)
Other assets | 581 | (1,578) | (4,580)
Accounts payable | 3,723 | 787 | 1,554
Accrued expenses | 6,994 | (6,057) | 3,208
Lease liabilities | (1,324) | 2,881 | 0
Deferred revenue | (8,472) | (20,869) | 13,405
Deferred rent | 0 | 0 | (971)
Net cash provided by (used in) operating activities | (111,898) | (134,270) | (153,234)
Cash flows from investing activities |  |  |
Purchases of marketable securities | (223,745) | (264,399) | (132,750)
Proceeds from sales and maturities of marketable securities | 221,866 | 189,330 | 214,348
Purchases of property, equipment and software | (5,906) | (4,289) | (24,954)
Net cash used in investing activities | (7,785) | (79,358) | 56,644
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of offering costs | 170,456 | 118,657 | 103,259
Proceeds from stock option exercises and ESPP purchases | 5,898 | 1,315 | 1,992
Purchase of treasury stock | (2,012) | 0 | (260)
Net cash provided by financing activities | 174,342 | 119,972 | 104,991
Net change in cash and cash equivalents | 54,659 | (93,656) | 8,401
Cash and cash equivalents at beginning of period | 126,472 | 220,128 | 211,727
Cash and cash equivalents at end of period | 181,131 | 126,472 | 220,128
Non-cash operating and investing activities: |  |  |
Right-of-use assets modified in exchange for operating lease obligation | 0 | 6,408 | 0
Fair value of warrants received | $ 0 | $ 0 | $ 6,130

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