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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Cumulative Effect, Period of Adoption, Adjustment
Common Stock
Treasury Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjustment
Accumulated Other Comprehensive Loss
Balance (in shares) at Dec. 31, 2017     36,859,077 0        
Balance at Dec. 31, 2017 $ 299,238 $ (6,478) $ 369 $ 0 $ 611,270 $ (312,340) $ (6,478) $ (61)
Share-based compensation 16,520       16,520      
Issuance of common stock, net of offering costs (in shares)     5,175,000          
Issuance of common stock, net of offering costs 103,259   $ 52   103,207      
Stock plan related activity (in shares)     319,224 11,070        
Stock plan related activity 1,733   $ 3 $ (260) 1,990      
Retirement of treasury stock (in shares)       (11,070)        
Retirement of treasury stock 0     $ 260 (260)      
Unrealized gain on investments 58             58
Net loss (171,453)         (171,453)    
Balance (in shares) at Dec. 31, 2018     42,353,301 0        
Balance at Dec. 31, 2018 242,877   $ 424 $ 0 732,727 (490,271)   (3)
Share-based compensation 19,571       19,571      
Issuance of common stock, net of offering costs (in shares)     6,325,000          
Issuance of common stock, net of offering costs 118,657   $ 63   118,594      
Stock plan related activity (in shares)     280,462          
Stock plan related activity 1,315   $ 3   1,312      
Unrealized gain on investments 19             19
Net loss (151,811)         (151,811)    
Balance (in shares) at Dec. 31, 2019     48,958,763 0        
Balance at Dec. 31, 2019 230,628   $ 490 $ 0 872,204 (642,082)   16
Share-based compensation 20,676       20,676      
Issuance of common stock, net of offering costs (in shares)     6,612,815          
Issuance of common stock, net of offering costs 170,456   $ 66   170,390      
Stock plan related activity (in shares)     673,193 74,632        
Stock plan related activity 3,886   $ 6 $ (2,012) 5,892      
Retirement of treasury stock (in shares)       (74,632)        
Retirement of treasury stock 0     $ 2,012 (2,012)      
Unrealized gain on investments (23)             (23)
Net loss (129,739)         (129,739)    
Balance (in shares) at Dec. 31, 2020     56,244,771 0        
Balance at Dec. 31, 2020 $ 295,884   $ 562 $ 0 $ 1,067,150 $ (771,821)   $ (7)