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Collaboration and Other Agreements - Provention (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
May 31, 2018
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Collaboration and Other Agreements [Line Items]        
Revenues   $ 104,883 $ 64,188 $ 60,121
Deferred revenue   4,456 10,700  
Deferred revenue included in long-term liabilities   $ 6,926 $ 9,153  
Provention Bio, Inc. (Provention)        
Collaboration and Other Agreements [Line Items]        
Transaction price $ 6,100      
Stock warrants (in shares) 2,432,688      
Provention License Agreement | Provention PRV3279 | Provention Bio, Inc. (Provention)        
Collaboration and Other Agreements [Line Items]        
Consideration received common stock warrant exercise price (in usd per share) $ 2.50      
Potential development and regulatory milestone payments $ 65,000      
Potential commercial milestone payments $ 225,000      
Asset Purchase Agreement | Provention PRV031 | Provention Bio, Inc. (Provention)        
Collaboration and Other Agreements [Line Items]        
Consideration received common stock warrant exercise price (in usd per share) $ 2.50      
Potential development and regulatory milestone payments $ 170,000      
Potential commercial milestone payments 225,000      
Potential milestone payment to third parties for intellectual property under agreement 1,300      
Revenues From License Agreements | Provention Bio, Inc. (Provention)        
Collaboration and Other Agreements [Line Items]        
Revenues $ 6,100