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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance (in shares) at Dec. 31, 2019   48,958,763      
Beginning balance at Dec. 31, 2019 $ 230,628 $ 490 $ 872,204 $ (642,082) $ 16
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 4,451   4,451    
Stock plan related activity (in shares)   172,387      
Stock plan related activity 162 $ 2 160    
Unrealized gain (loss) on investments 56       56
Net loss (44,724)     (44,724)  
Ending balance (in shares) at Mar. 31, 2020   49,131,150      
Ending balance at Mar. 31, 2020 190,573 $ 492 876,815 (686,806) 72
Beginning balance (in shares) at Dec. 31, 2020   56,244,771      
Beginning balance at Dec. 31, 2020 295,884 $ 562 1,067,150 (771,821) (7)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,243   5,243    
Issuance of common stock, net of offering costs (in shares)   3,622,186      
Issuance of common stock, net of offering costs $ 98,200 $ 36 98,164    
Stock plan related activity (in shares) 1,555,796 144,249      
Stock plan related activity $ 2,458 $ 2 2,456    
Unrealized gain (loss) on investments 18       18
Net loss (51,272)     (51,272)  
Ending balance (in shares) at Mar. 31, 2021   60,011,206      
Ending balance at Mar. 31, 2021 $ 350,531 $ 600 $ 1,173,013 $ (823,093) $ 11