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Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2021

Share-based Payment Arrangement [Abstract]

Stock-Based Compensation Expense

The following stock-based compensation expense was recognized for the periods indicated (in thousands):

			Three Months Ended June 30,												Six Months Ended June 30,
			2021						2020						2021						2020
Research and development			$	3,058					$	2,589					$	5,785					$	5,023
Selling, general and administrative			3,012						2,506						5,571						4,564
Total stock-based compensation expense			$	6,070					$	5,095					$	11,356					$	9,587

Valuation Assumptions Using the Black-Scholes Option-Pricing Model

The fair value of each option award is estimated on the date of grant using the Black-Scholes option-pricing model using the assumptions in the following table for options issued during the period indicated:

			Six Months Ended June 30,
			2021						2020
Expected dividend yield			0%						0%
Expected volatility			86.2% -86.7%						67.3% - 108.8%
Risk-free interest rate			0.6% - 1.4%						0.5% - 1.8%
Expected term			6.25 years						6.25 years

Stock Option and Restricted Stock Unit Activity

The following table summarizes stock option activity during the six months ended June 30, 2021:

			Shares						Weighted- Average Exercise Price						Weighted-Average Remaining Contractual Term (Years)						Aggregate Intrinsic Value  (in thousands)
Outstanding, December 31, 2020			7,258,353						$	21.48					6.8
Granted			1,790,246						20.72
Exercised			(250,175)						18.35
Forfeited or expired			(187,526)						16.36
Outstanding, June 30, 2021			8,610,898						21.48						7.0						$	53,928
As of June 30, 2021:
Exercisable			4,957,615						22.96						5.6						25,634
Vested and expected to vest			8,194,010						21.58						6.9						50,662

Schedule of RSU Activity

The following table summarizes RSU activity during the six months ended June 30, 2021:

			Shares						Weighted-Average Grant Date Fair Value
Outstanding, December 31, 2020			209,250						$	15.92
Granted			10,500						29.17
Exercised			(7,500)						23.68
Forfeited or expired			(17,400)						15.32
Outstanding, June 30, 2021			194,850						16.39

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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