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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance (in shares) at Dec. 31, 2019   48,958,763      
Beginning balance at Dec. 31, 2019 $ 230,628 $ 490 $ 872,204 $ (642,082) $ 16
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 4,451   4,451    
Stock plan related activity (in shares)   172,387      
Stock plan related activity 162 $ 2 160    
Unrealized gain (loss) on investments 56       56
Net loss (44,724)     (44,724)  
Ending balance (in shares) at Mar. 31, 2020   49,131,150      
Ending balance at Mar. 31, 2020 190,573 $ 492 876,815 (686,806) 72
Beginning balance (in shares) at Dec. 31, 2019   48,958,763      
Beginning balance at Dec. 31, 2019 230,628 $ 490 872,204 (642,082) 16
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock plan related activity   $ 2      
Net loss (91,609)        
Ending balance (in shares) at Jun. 30, 2020   53,365,003      
Ending balance at Jun. 30, 2020 247,784 $ 534 980,924 (733,691) 17
Beginning balance (in shares) at Mar. 31, 2020   49,131,150      
Beginning balance at Mar. 31, 2020 190,573 $ 492 876,815 (686,806) 72
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,136   5,136    
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest (46,885)     (46,885)  
Issuance of common stock, net of offering costs (in shares)   4,060,482      
Issuance of common stock, net of offering costs 96,512 $ 40 96,472    
Stock plan related activity (in shares)   173,371      
Stock plan related activity 2,503   2,501    
Unrealized gain (loss) on investments (55)       (55)
Net loss (46,885)        
Ending balance (in shares) at Jun. 30, 2020   53,365,003      
Ending balance at Jun. 30, 2020 247,784 $ 534 980,924 (733,691) 17
Beginning balance (in shares) at Dec. 31, 2020   56,244,771      
Beginning balance at Dec. 31, 2020 295,884 $ 562 1,067,150 (771,821) (7)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,243   5,243    
Issuance of common stock, net of offering costs (in shares)   3,622,186      
Issuance of common stock, net of offering costs 98,200 $ 36 98,164    
Stock plan related activity (in shares)   144,249      
Stock plan related activity 2,458 $ 2 2,456    
Unrealized gain (loss) on investments 18       18
Net loss (51,272)     (51,272)  
Ending balance (in shares) at Mar. 31, 2021   60,011,206      
Ending balance at Mar. 31, 2021 350,531 $ 600 1,173,013 (823,093) 11
Beginning balance (in shares) at Dec. 31, 2020   56,244,771      
Beginning balance at Dec. 31, 2020 $ 295,884 $ 562 1,067,150 (771,821) (7)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock plan related activity (in shares) 1,790,246        
Net loss $ (91,207)        
Ending balance (in shares) at Jun. 30, 2021   60,133,447      
Ending balance at Jun. 30, 2021 319,045 $ 601 1,181,471 (863,028) 1
Beginning balance (in shares) at Mar. 31, 2021   60,011,206      
Beginning balance at Mar. 31, 2021 350,531 $ 600 1,173,013 (823,093) 11
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 6,113   6,113    
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest (39,935)     (39,935)  
Stock plan related activity (in shares)   122,241      
Stock plan related activity 2,346 $ 1 2,345    
Unrealized gain (loss) on investments (10)       (10)
Net loss (39,935)        
Ending balance (in shares) at Jun. 30, 2021   60,133,447      
Ending balance at Jun. 30, 2021 $ 319,045 $ 601 $ 1,181,471 $ (863,028) $ 1