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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities    
Net loss $ (144,093) $ (127,652)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 8,306 9,067
Amortization of premiums and discounts on marketable securities 1,267 (387)
Stock-based compensation 17,714 15,419
Other non-cash items 1,602 0
Changes in operating assets and liabilities:    
Accounts receivable 9,322 (6,033)
Inventory (5,582) 0
Prepaid expenses and other current assets (1,080) 654
Other assets 5,146 1,615
Accounts payable (1,931) 137
Accrued expenses and other current liabilities 7,744 5,499
Lease liabilities (2,701) (2,113)
Deferred revenue 14,507 (4,816)
Other non current liabilities 258 2,245
Net cash used in operating activities (89,521) (106,365)
Cash flows from investing activities    
Purchases of marketable securities (164,780) (151,230)
Proceeds from sale and maturities of marketable securities 146,550 161,866
Purchases of property, equipment and software (4,826) (2,346)
Net cash provided by (used in) investing activities (23,056) 8,290
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 117,818 170,494
Proceeds from stock option exercises and ESPP purchases 5,722 4,757
Taxes paid related to net share settlement of equity awards (1,563) (2,011)
Net cash provided by financing activities 121,977 173,240
Net change in cash and cash equivalents 9,400 75,165
Cash and cash equivalents at beginning of period 181,131 126,472
Cash and cash equivalents at end of period 190,531 201,637
Supplemental Cash Flow Information [Abstract]    
Property, equipment and software included in accounts payable or accruals $ 69 $ 0