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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Details) - USD ($)
$ in Thousands
Dec. 31, 2021
Dec. 31, 2020
Deferred income tax assets:    
Federal U.S. net operating loss carryforward $ 175,802 $ 136,086
State net operating loss carryforward 49,965 37,465
Research and development credit, net 60,514 50,271
Orphan drug credit, net 24,858 23,409
Operating lease liabilities 7,008 8,048
Deferred revenue 1,245 3,132
Other 16,727 14,285
Gross deferred income tax assets 336,119 272,696
Valuation allowance (327,595) (263,403)
Net deferred income tax assets 8,524 9,293
Deferred income tax liabilities:    
Depreciation (1,688) (2,123)
Operating lease ROU assets (4,576) (5,316)
Prepaid expenditures (2,260) (1,854)
Gross deferred income tax liabilities (8,524) (9,293)
Net deferred income tax asset/(liability) $ 0 $ 0