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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues:      
Revenues $ 77,447 $ 104,883 $ 64,188
Costs and expenses:      
Cost of product sales 2,651 0 0
Research and development 214,577 193,201 195,309
Selling, general and administrative 63,014 42,742 46,064
Total costs and expenses 280,242 235,943 241,373
Loss from operations (202,795) (131,060) (177,185)
Other income 680 1,321 25,374
Net loss (202,115) (129,739) (151,811)
Other comprehensive income:      
Unrealized gain (loss) on investments (54) (23) 19
Comprehensive loss $ (202,169) $ (129,762) $ (151,792)
Basic net loss per common share (in usd per share) $ (3.37) $ (2.47) $ (3.16)
Diluted net loss per common share (in usd per share) $ (3.37) $ (2.47) $ (3.16)
Basic weighted average number of common shares outstanding (in shares) 59,944,717 52,442,389 48,082,728
Diluted weighted average number of common shares outstanding (in shares) 59,944,717 52,442,389 48,082,728
Revenue from collaborative agreements      
Revenues:      
Revenues $ 63,294 $ 97,764 $ 62,024
Revenue from government agreements      
Revenues:      
Revenues 1,804 7,119 2,164
Product      
Revenues:      
Revenues $ 12,349 $ 0 $ 0