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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenues:    
Revenues $ 11,101 $ 16,881
Costs and expenses:    
Cost of product sales 48 17
Research and development 61,438 53,121
Selling, general and administrative 16,253 15,036
Total costs and expenses 77,739 68,174
Loss from operations (66,638) (51,293)
Other income 195 21
Net loss (66,443) (51,272)
Other comprehensive income (loss):    
Unrealized gain (loss) on investments (222) 18
Comprehensive income (loss) $ (66,665) $ (51,254)
Basic net loss per common share (in usd per share) $ (1.08) $ (0.90)
Diluted net loss per common share (in usd per share) $ (1.08) $ (0.90)
Basic weighted average common shares outstanding (in shares) 61,324,163 57,202,846
Diluted weighted average common shares outstanding (in shares) 61,324,163 57,202,846
Revenue from collaborative and other agreements    
Revenues:    
Revenues $ 7,093 $ 15,184
Product revenue, net    
Revenues:    
Revenues 3,580 887
Revenue from government agreements    
Revenues:    
Revenues $ 428 $ 810