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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities    
Net loss $ (66,443) $ (51,272)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 2,913 2,729
Amortization of premiums and discounts on marketable securities 334 367
Stock-based compensation 5,274 5,286
Changes in operating assets and liabilities:    
Accounts receivable (4,520) 15,934
Inventory (210) (6,172)
Prepaid expenses and other current assets 6,457 (1,239)
Other non current assets 801 3,673
Accounts payable (11,920) 1,829
Accrued expenses and other current liabilities (543) 855
Lease liabilities (1,119) (683)
Deferred revenue 11,280 (601)
Other non current liabilities 0 258
Net cash used in operating activities (57,696) (29,036)
Cash flows from investing activities    
Purchases of marketable securities (54,077) (93,881)
Proceeds from sale and maturities of marketable securities 37,010 60,250
Purchases of property, equipment and software (1,415) (626)
Net cash used in investing activities (18,482) (34,257)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 0 98,200
Proceeds from stock option exercises 37 2,458
Net cash provided by financing activities 37 100,658
Net change in cash and cash equivalents (76,141) 37,365
Cash and cash equivalents at beginning of period 123,469 181,131
Cash and cash equivalents at end of period 47,328 218,496
Supplemental Cash Flow Information [Abstract]    
Property, equipment and software included in accounts payable or accruals $ 151 $ 486