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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Revenues:        
Revenues $ 26,007 $ 30,757 $ 37,108 $ 47,638
Costs and expenses:        
Cost of product sales 180 22 228 39
Cost of manufacturing services 2,222 0 2,222 0
Research and development 51,744 55,780 113,182 108,901
Selling, general and administrative 13,669 15,234 29,922 30,270
Total costs and expenses 67,815 71,036 145,554 139,210
Loss from operations (41,808) (40,279) (108,446) (91,572)
Other income 504 344 699 365
Net loss (41,304) (39,935) (107,747) (91,207)
Other comprehensive loss:        
Unrealized gain (loss) on investments (43) (10) (265) 8
Comprehensive loss $ (41,347) $ (39,945) $ (108,012) $ (91,199)
Basic net loss per common share (in usd per share) $ (0.67) $ (0.66) $ (1.76) $ (1.56)
Diluted net loss per common share (in usd per share) $ (0.67) $ (0.66) $ (1.76) $ (1.56)
Basic weighted average common shares outstanding (in shares) 61,384,943 60,068,315 61,354,721 58,643,496
Diluted weighted average common shares outstanding (in shares) 61,384,943 60,068,315 61,354,721 58,643,496
Collaborative and other agreements        
Revenues:        
Revenues $ 16,863 $ 27,168 $ 23,956 $ 42,352
Product sales, net        
Revenues:        
Revenues 4,672 3,203 8,252 4,090
Government agreements        
Revenues:        
Revenues 480 386 908 1,196
Contract Manufacturing        
Revenues:        
Revenues $ 3,992 $ 0 $ 3,992 $ 0