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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities    
Net loss $ (132,560) $ (144,093)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 8,634 8,306
Amortization of premiums and discounts on marketable securities 740 1,267
Stock-based compensation 15,697 17,714
Other non-cash items 2,882 1,602
Changes in operating assets and liabilities:    
Accounts receivable (3,452) 9,322
Inventory 419 (5,582)
Prepaid expenses and other current assets 11,898 (1,080)
Other non current assets 2,468 5,146
Accounts payable (10,897) (1,931)
Accrued expenses and other current liabilities (184) 7,744
Lease liabilities (3,447) (2,701)
Deferred revenue (8,477) 14,507
Other non current liabilities 0 258
Net cash used in operating activities (116,279) (89,521)
Cash flows from investing activities    
Purchases of marketable securities (75,457) (164,780)
Proceeds from sale and maturities of marketable securities 155,190 146,550
Purchases of property, equipment and software (3,230) (4,826)
Net cash provided by (used in) investing activities 76,503 (23,056)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 0 117,818
Proceeds from stock option exercises and ESPP Purchases 314 5,722
Taxes paid related to net share settlement of equity awards (14) (1,563)
Net cash provided by financing activities 300 121,977
Net change in cash and cash equivalents (39,476) 9,400
Cash and cash equivalents at beginning of period 123,469 181,131
Cash and cash equivalents at end of period 83,993 190,531
Supplemental Cash Flow Information [Abstract]    
Property, equipment and software included in accounts payable or accruals $ 295 $ 69