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Revenue - Provention (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2022 | May 31, 2018 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Revenues |  |  | $ 151,941 | $ 77,447 | $ 104,883
Provention Bio, Inc. (Provention) |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Transaction price |  | $ 6,100 |  |  |
Stock warrants (in shares) |  | 2,432,688 |  |  |
Provention License Agreement | Provention PRV3279 | Provention Bio, Inc. (Provention) |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Consideration received common stock warrant exercise price (in usd per share) |  | $ 2.50 |  |  |
Potential development and regulatory milestone payments |  | $ 65,000 |  |  |
Potential commercial milestone payments |  | $ 225,000 |  |  |
Asset Purchase Agreement | Provention PRV031 | Provention Bio, Inc. (Provention) |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Consideration received common stock warrant exercise price (in usd per share) |  | $ 2.50 |  |  |
Potential development and regulatory milestone payments |  | $ 170,000 |  |  |
Potential commercial milestone payments |  | 225,000 |  |  |
Potential milestone payment to third parties for intellectual property under agreement |  | 1,300 |  |  |
Revenues |  |  | 60,000 | $ 1,300 | $ 600
Provention Bio Milestone Revenue in A/R |  |  | 45,000 |  |
Amounts recognized | $ 60,000 |  |  |  |
Revenues From License Agreements | Provention Bio, Inc. (Provention) |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Revenues |  | $ 6,100 |  |  |
Provention Bio CMO Agreeemnt | Provention Bio, Inc. (Provention) |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Revenues |  |  | 5,300 |  |
upfront and fixed payments |  |  | $ 4,600 |  |

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