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Revenue - Provention (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Nov. 30, 2022
May 31, 2018
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Collaboration and Other Agreements [Line Items]          
Revenues     $ 151,941 $ 77,447 $ 104,883
Provention Bio, Inc. (Provention)          
Collaboration and Other Agreements [Line Items]          
Transaction price   $ 6,100      
Stock warrants (in shares)   2,432,688      
Provention License Agreement | Provention PRV3279 | Provention Bio, Inc. (Provention)          
Collaboration and Other Agreements [Line Items]          
Consideration received common stock warrant exercise price (in usd per share)   $ 2.50      
Potential development and regulatory milestone payments   $ 65,000      
Potential commercial milestone payments   $ 225,000      
Asset Purchase Agreement | Provention PRV031 | Provention Bio, Inc. (Provention)          
Collaboration and Other Agreements [Line Items]          
Consideration received common stock warrant exercise price (in usd per share)   $ 2.50      
Potential development and regulatory milestone payments   $ 170,000      
Potential commercial milestone payments   225,000      
Potential milestone payment to third parties for intellectual property under agreement   1,300      
Revenues     60,000 $ 1,300 $ 600
Provention Bio Milestone Revenue in A/R     45,000    
Amounts recognized $ 60,000        
Revenues From License Agreements | Provention Bio, Inc. (Provention)          
Collaboration and Other Agreements [Line Items]          
Revenues   $ 6,100      
Provention Bio CMO Agreeemnt | Provention Bio, Inc. (Provention)          
Collaboration and Other Agreements [Line Items]          
Revenues     5,300    
upfront and fixed payments     $ 4,600