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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Details) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Deferred income tax assets:    
Federal U.S. net operating loss carryforward $ 163,071 $ 175,802
State net operating loss carryforward 44,784 49,965
Research and development credit, net 65,084 60,514
Orphan drug credit, net 35,703 24,858
Operating lease liabilities 9,585 7,008
Deferred revenue 0 1,245
Section 174 deferred tax asset 43,192 0
Depreciation 158 0
Other 19,733 16,727
Gross deferred income tax assets 381,310 336,119
Valuation allowance (372,267) (327,595)
Net deferred income tax assets 9,043 8,524
Deferred income tax liabilities:    
Depreciation 0 (1,688)
Operating lease ROU assets (7,522) (4,576)
Prepaid expenditures (1,521) (2,260)
Gross deferred income tax liabilities (9,043) (8,524)
Net deferred income tax asset/(liability) $ 0 $ 0