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Income Taxes - Reconciliation of Reported Estimated Income Tax Benefit (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
United States federal tax at statutory rate	$ (25,149)	$ (42,445)	$ (27,245)
State taxes (net of federal benefit)	(7,385)	(12,806)	(8,100)
Deferred income tax adjustments	308	473	344
Research credit, net	(4,569)	(10,243)	(14,691)
Orphan drug credit, net	(10,846)	(1,449)	(528)
Other permanent items	1,362	1,199	1,156
Equity-based compensation	1,604	1,079	554
Change in valuation allowance	44,675	64,192	48,510
Income tax expense/(benefit)	$ 0	$ 0	$ 0

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to deferred tax adjustments.

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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