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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Loss
Balance (in shares) at Dec. 31, 2019   48,958,763      
Balance at Dec. 31, 2019 $ 230,628 $ 490 $ 872,204 $ (642,082) $ 16
Share-based compensation 20,676   20,676    
Issuance of common stock, net of offering costs (in shares)   6,612,815      
Issuance of common stock, net of offering costs 170,456 $ 66 170,390    
Stock plan related activity (in shares)   673,193      
Stock plan related activity 3,886 $ 6 3,880    
Unrealized Gain (Loss) on Investments (23)       (23)
Net loss (129,739)     (129,739)  
Balance (in shares) at Dec. 31, 2020   56,244,771      
Balance at Dec. 31, 2020 295,884 $ 562 1,067,150 (771,821) (7)
Share-based compensation 23,126   23,126    
Issuance of common stock, net of offering costs (in shares)   4,580,653      
Issuance of common stock, net of offering costs 117,818 $ 46 117,772    
Stock plan related activity (in shares)   482,004      
Stock plan related activity 4,959 $ 5 4,954    
Unrealized Gain (Loss) on Investments (54)       (54)
Net loss (202,115)     (202,115)  
Balance (in shares) at Dec. 31, 2021   61,307,428      
Balance at Dec. 31, 2021 239,618 $ 613 1,213,002 (973,936) (61)
Share-based compensation 20,438   20,438    
Issuance of common stock, net of offering costs (in shares)   160,480      
Issuance of common stock, net of offering costs 1,085 $ 2 1,083    
Stock plan related activity (in shares)   233,559      
Stock plan related activity 574 $ 2 572    
Unrealized Gain (Loss) on Investments 56       56
Net loss (119,758)     (119,758)  
Balance (in shares) at Dec. 31, 2022   61,701,467      
Balance at Dec. 31, 2022 $ 142,013 $ 617 $ 1,235,095 $ (1,093,694) $ (5)