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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Operating activities      
Net loss $ (119,758) $ (202,115) $ (129,739)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation and amortization 11,865 11,258 11,957
Amortization of premiums and discounts on marketable securities 403 1,607 (260)
Share-based compensation 20,438 23,126 20,676
Other non-cash items 2,882 2,035 0
Changes in operating assets and liabilities:      
Accounts receivable (45,836) 12,696 (10,337)
Inventory 55 (6,424) 0
Prepaid expenses and other current assets 11,009 (4,188) (5,697)
Other non current assets (10,704) 5,915 581
Accounts payable (10,860) 7,125 3,723
Accrued expenses and other current liabilities (4,638) (607) 6,994
Lease liabilities 9,364 (3,780) (1,324)
Deferred revenue 48,821 9,264 (8,472)
Other non current liabilities 0 258 0
Net Cash Provided by (Used in) Operating Activities, Total (86,959) (143,830) (111,898)
Cash flows from investing activities      
Purchases of marketable securities (120,602) (231,208) (223,745)
Proceeds from sales and maturities of marketable securities 194,940 200,800 221,866
Purchases of property, equipment and software (3,623) (6,201) (5,906)
Net Cash Provided by (Used in) Investing Activities, Total 70,715 (36,609) (7,785)
Cash flows from financing activities      
Proceeds from issuance of common stock, net of offering costs 1,085 117,818 170,456
Proceeds from stock option exercises and ESPP purchases 574 4,959 3,886
Net Cash Provided by (Used in) Financing Activities, Total 1,659 122,777 174,342
Net change in cash and cash equivalents (14,585) (57,662) 54,659
Cash and cash equivalents at beginning of period 123,469 181,131 126,472
Cash and cash equivalents at end of period 108,884 123,469 181,131
Non-cash operating and investing activities      
Capital Expenditures Incurred but Not yet Paid $ 118 $ 508 $ 66