    <SEC-DOCUMENT>0001125345-23-000069-index.html : 20230417
    <SEC-HEADER>0001125345-23-000069.hdr.sgml : 20230417
    <ACCEPTANCE-DATETIME>20230417160323
    ACCESSION NUMBER:		0001125345-23-000069
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230417
    DATE AS OF CHANGE:		20230417
    EFFECTIVENESS DATE:		20230417

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			MACROGENICS INC
    		CENTRAL INDEX KEY:			0001125345
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-36112
    		FILM NUMBER:		23823964

    	BUSINESS ADDRESS:
    		STREET 1:		9704 MEDICAL CENTER DRIVE
    		CITY:			Rockville
    		STATE:			MD
    		ZIP:			20850
    		BUSINESS PHONE:		301-251-5172

    	MAIL ADDRESS:
    		STREET 1:		9704 MEDICAL CENTER DRIVE
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>annualreportpdfforfiling.pdf
    <DESCRIPTION>2022 ANN REPORT TO SHAREHOLDERS
    <TEXT>
    Document 1 - file: annualreportpdfforfiling.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>