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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities    
Net loss $ (38,009) $ (66,443)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 2,983 2,913
Amortization of premiums and discounts on marketable securities (372) 334
Stock-based compensation 4,833 5,274
Non-cash royalty revenue (90) 0
Non-cash interest expense recognized 656 0
Changes in operating assets and liabilities:    
Accounts receivable 20,062 (4,520)
Inventory 42 (210)
Prepaid expenses and other current assets 443 6,457
Non-cash lease expense 941 0
Other non current assets 0 801
Accounts payable (1,148) (11,920)
Accrued expenses and other current liabilities (677) (543)
Lease liabilities (284) (1,119)
Deferred revenue (2,213) 11,280
Net cash used in operating activities (12,833) (57,696)
Cash flows from investing activities    
Purchases of marketable securities (17,296) (54,077)
Proceeds from sale and maturities of marketable securities 45,750 37,010
Purchases of property, equipment and software (359) (1,415)
Net cash provided by (used in) investing activities 28,095 (18,482)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of offering costs 616 0
Proceeds from stock option exercises and ESPP purchases 5 37
Taxes paid related to net share settlement of equity awards (158) 0
Net proceeds from sale of future royalties 99,655 0
Net cash provided by financing activities 100,118 37
Net change in cash and cash equivalents 115,380 (76,141)
Cash and cash equivalents at beginning of period 108,884 123,469
Cash and cash equivalents at end of period 224,264 47,328
Supplemental Cash Flow Information [Abstract]    
Property, equipment and software included in accounts payable or accruals $ 177 $ 151