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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance (in shares) at Dec. 31, 2021   61,307,428      
Beginning balance at Dec. 31, 2021 $ 239,618 $ 613 $ 1,213,002 $ (973,936) $ (61)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,224   5,224    
Stock plan activity (in shares)   25,646      
Stock plan related activity 37   37    
Unrealized gain (loss) on investments (222)       (222)
Net loss (66,443)     (66,443)  
Ending balance (in shares) at Mar. 31, 2022   61,333,074      
Ending balance at Mar. 31, 2022 178,214 $ 613 1,218,263 (1,040,379) (283)
Beginning balance (in shares) at Dec. 31, 2021   61,307,428      
Beginning balance at Dec. 31, 2021 239,618 $ 613 1,213,002 (973,936) (61)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (132,560)        
Ending balance (in shares) at Sep. 30, 2022   61,462,189      
Ending balance at Sep. 30, 2022 122,958 $ 615 1,228,952 (1,106,496) (113)
Beginning balance (in shares) at Mar. 31, 2022   61,333,074      
Beginning balance at Mar. 31, 2022 178,214 $ 613 1,218,263 (1,040,379) (283)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,350   5,350    
Stock plan related activity 264 $ 2 262    
Shares, Granted (in shares)   125,716      
Unrealized gain (loss) on investments (43)       (43)
Net loss (41,304)     (41,304)  
Ending balance (in shares) at Jun. 30, 2022   61,458,790      
Ending balance at Jun. 30, 2022 142,481 $ 615 1,223,875 (1,081,683) (326)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 5,077   5,077    
Shares, Granted (in shares)   3,399      
Unrealized gain (loss) on investments 213       213
Net loss (24,813)     (24,813)  
Ending balance (in shares) at Sep. 30, 2022   61,462,189      
Ending balance at Sep. 30, 2022 122,958 $ 615 1,228,952 (1,106,496) (113)
Beginning balance (in shares) at Dec. 31, 2022   61,701,467      
Beginning balance at Dec. 31, 2022 142,013 $ 617 1,235,095 (1,093,694) (5)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 4,788   4,788    
Stock plan activity (in shares)   42,098      
Stock plan related activity (154)   (154)    
Issuance of common stock, net of offering costs (in shares)   95,000      
Issuance of common stock, net of offering costs 617 $ 1 616    
Unrealized gain (loss) on investments 13       13
Net loss (38,009)     (38,009)  
Ending balance (in shares) at Mar. 31, 2023   61,838,565      
Ending balance at Mar. 31, 2023 109,268 $ 618 1,240,345 (1,131,703) 8
Beginning balance (in shares) at Dec. 31, 2022   61,701,467      
Beginning balance at Dec. 31, 2022 $ 142,013 $ 617 1,235,095 (1,093,694) (5)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Shares, Granted (in shares) 3,267,727        
Net loss $ 37,014        
Ending balance (in shares) at Sep. 30, 2023   62,028,904      
Ending balance at Sep. 30, 2023 193,980 $ 620 1,250,074 (1,056,680) (34)
Beginning balance (in shares) at Mar. 31, 2023   61,838,565      
Beginning balance at Mar. 31, 2023 109,268 $ 618 1,240,345 (1,131,703) 8
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 4,436   4,436    
Stock plan related activity 216 $ 1 215    
Shares, Granted (in shares)   63,793      
Issuance of common stock, net of offering costs (in shares)   36,135      
Issuance of common stock, net of offering costs 235   235    
Unrealized gain (loss) on investments (80)       (80)
Net loss 57,469     57,469  
Ending balance (in shares) at Jun. 30, 2023   61,938,493      
Ending balance at Jun. 30, 2023 171,544 $ 619 1,245,231 (1,074,234) (72)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Share-based compensation 4,746   4,746    
Stock plan related activity (89) $ 1      
Shares, Granted (in shares)   54,276      
Stock plan related activity     (90)    
Issuance of common stock, net of offering costs (in shares)   36,135      
Issuance of common stock, net of offering costs 187   187    
Unrealized gain (loss) on investments 38       38
Net loss 17,554     17,554  
Ending balance (in shares) at Sep. 30, 2023   62,028,904      
Ending balance at Sep. 30, 2023 $ 193,980 $ 620 $ 1,250,074 $ (1,056,680) $ (34)