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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities |  |  |
Net loss | $ (9,058) | $ (119,758) | $ (202,115)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 9,645 | 11,865 | 11,258
Amortization of premiums and discounts on marketable securities | (5,004) | 403 | 1,607
Share-based compensation | 18,373 | 20,438 | 23,126
Gain on royalty monetization arrangement | (150,930) | 0 | 0
Non-cash interest expense | 1,430 | 0 | 0
Non-cash lease expense | 3,489 | 3,341 | 2,690
Other non-cash items | 423 | 2,882 | 2,035
Loss on disposal of assets | 111 | 0 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 45,855 | (45,836) | 12,696
Inventory | 230 | 55 | (6,424)
Prepaid expenses and other current assets | 215 | 11,009 | (4,188)
Other non current assets | (7) | (14,045) | 3,225
Accounts payable | 1,281 | (10,860) | 7,125
Accrued expenses and other current liabilities | (4,823) | (4,638) | (607)
Lease liabilities | (861) | 9,364 | (3,780)
Deferred revenue | 11,426 | 48,821 | 9,264
Other non current liabilities | 0 | 0 | 258
Net cash used in operating activities | (78,205) | (86,959) | (143,830)
Cash flows from investing activities |  |  |
Purchases of marketable securities | (239,683) | (120,602) | (231,208)
Proceeds from sales and maturities of marketable securities | 161,299 | 194,940 | 200,800
Purchases of property, equipment and software | (1,764) | (3,623) | (6,201)
Proceeds from sales of equipment | 64 | 0 | 0
Net cash provided by (used in) investing activities | (80,084) | 70,715 | (36,609)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of offering costs | 616 | 1,085 | 117,818
Proceeds from stock option exercises and ESPP purchases | 553 | 574 | 4,959
Taxes paid related to net share settlement of equity awards | (306) | 0 |
Principal payments on royalty monetization arrangement | (157) | 0 | 0
Net proceeds from sale of future royalties | 149,655 | 0 | 0
Net cash provided by financing activities | 150,361 | 1,659 | 122,777
Net change in cash and cash equivalents | (7,928) | (14,585) | (57,662)
Cash and cash equivalents at beginning of period | 108,884 | 123,469 | 181,131
Cash and cash equivalents at end of period | 100,956 | 108,884 | 123,469
Non-cash operating and investing activities |  |  |
Capital Expenditures Incurred but Not yet Paid | $ 505 | $ 118 | $ 508

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