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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Loss
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2020 |  | 56,244,771 |  |  |
Balance at Dec. 31, 2020 | $ 295,884 | $ 562 | $ 1,067,150 | $ (771,821) | $ (7)
Share-based compensation | 23,126 |  | 23,126 |  |
Issuance of common stock, net of offering costs (in shares) |  | 4,580,653 |  |  |
Issuance of common stock, net of offering costs | 117,818 | $ 46 | 117,772 |  |
Stock plan related activity (in shares) |  | 482,004 |  |  |
Stock plan related activity | 4,959 | $ 5 | 4,954 |  |
Unrealized Gain (Loss) on Investments | (54) |  |  |  | (54)
Net loss | (202,115) |  |  | (202,115) |
Balance (in shares) at Dec. 31, 2021 |  | 61,307,428 |  |  |
Balance at Dec. 31, 2021 | 239,618 | $ 613 | 1,213,002 | (973,936) | (61)
Share-based compensation | 20,438 |  | 20,438 |  |
Issuance of common stock, net of offering costs (in shares) |  | 160,480 |  |  |
Issuance of common stock, net of offering costs | 1,085 | $ 2 | 1,083 |  |
Stock plan related activity (in shares) |  | 233,559 |  |  |
Stock plan related activity | 574 | $ 2 | 572 |  |
Unrealized Gain (Loss) on Investments | 56 |  |  |  | 56
Net loss | (119,758) |  |  | (119,758) |
Balance (in shares) at Dec. 31, 2022 |  | 61,701,467 |  |  |
Balance at Dec. 31, 2022 | 142,013 | $ 617 | 1,235,095 | (1,093,694) | (5)
Share-based compensation | 18,373 |  | 18,373 |  |
Issuance of common stock, net of offering costs (in shares) |  | 167,270 |  |  |
Issuance of common stock, net of offering costs | 1,039 | $ 2 | 1,037 |  |
Stock plan related activity (in shares) |  | 201,890 |  |  |
Stock plan related activity | 247 | $ 2 | 245 |  |
Unrealized Gain (Loss) on Investments | (1) |  |  |  | (1)
Net loss | (9,058) |  |  | (9,058) |
Balance (in shares) at Dec. 31, 2023 |  | 62,070,627 |  |  |
Balance at Dec. 31, 2023 | $ 152,613 | $ 621 | $ 1,254,750 | $ (1,102,752) | $ (6)

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