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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Revenues:      
Revenues $ 58,749 $ 151,941 $ 77,447
Costs and expenses:      
Cost of product sales 619 3,351 2,651
Cost of manufacturing services 7,603 4,033 0
Research and development 166,583 207,026 214,577
Selling, general and administrative 52,188 58,949 63,014
Total costs and expenses 226,993 273,359 280,242
Loss from operations (168,244) (121,418) (202,795)
Gain on royalty monetization arrangement 150,930 0 0
Interest and other income 9,686 1,660 680
Interest expense (1,430) 0 0
Net loss (9,058) (119,758) (202,115)
Other comprehensive income (loss):      
Unrealized gain (loss) on investments (1) 56 (54)
Comprehensive loss $ (9,059) $ (119,702) $ (202,169)
Basic and diluted net loss per common share, basic (in dollars per share) $ (0.15) $ (1.95) $ (3.37)
Basic and diluted net loss per common share, diluted (in dollars per share) $ (0.15) $ (1.95) $ (3.37)
Basic weighted average number of common shares outstanding (in shares) 61,929,198 61,433,124 59,944,717
Diluted weighted average number of common shares outstanding (in shares) 61,929,198 61,433,124 59,944,717
Revenue from collaborative agreements      
Revenues:      
Revenues $ 28,990 $ 119,303 $ 63,294
Revenue from government agreements      
Revenues:      
Revenues 1,556 1,923 1,804
Product      
Revenues:      
Revenues 17,939 16,727 12,349
Contract Manufacturing      
Revenues:      
Revenues 9,833 13,988 0
RevenueFromRoyalityAgreementsMember      
Revenues:      
Revenues $ 431 $ 0 $ 0