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Income Taxes - Reconciliation of Reported Estimated Income Tax Benefit (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
United States federal tax at statutory rate	$ (1,902)	$ (25,149)	$ (42,445)
State taxes (net of federal benefit)	(163)	(7,385)	(12,806)
Deferred income tax adjustments	5,024	308	473
Deferred state blended rate adjustments	1,841	0	0
Research credit, net	(3,168)	(4,569)	(10,243)
Orphan drug credit, net	2,374	(10,846)	(1,449)
Other permanent items	1,301	1,362	1,199
Equity-based compensation	1,950	1,604	1,079
Change in valuation allowance	(7,257)	44,675	64,192
Income tax expense/(benefit)	$ 0	$ 0	$ 0

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