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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating activities      
Net loss $ (9,058) $ (119,758) $ (202,115)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation and amortization 9,645 11,865 11,258
Amortization of premiums and discounts on marketable securities (5,004) 403 1,607
Share-based compensation 18,373 20,438 23,126
Gain on royalty monetization arrangement (150,930) 0 0
Non-cash interest expense 1,430 0 0
Non-cash lease expense 3,489 3,341 2,690
Other non-cash items 423 2,882 2,035
Loss on disposal of assets 111 0 0
Changes in operating assets and liabilities:      
Accounts receivable 45,855 (45,836) 12,696
Inventory 230 55 (6,424)
Prepaid expenses and other current assets 215 11,009 (4,188)
Other non current assets (7) (14,045) 3,225
Accounts payable 1,281 (10,860) 7,125
Accrued expenses and other current liabilities (4,823) (4,638) (607)
Lease liabilities (861) 9,364 (3,780)
Deferred revenue 11,426 48,821 9,264
Other non current liabilities 0 0 258
Net cash used in operating activities (78,205) (86,959) (143,830)
Cash flows from investing activities      
Purchases of marketable securities (239,683) (120,602) (231,208)
Proceeds from sales and maturities of marketable securities 161,299 194,940 200,800
Purchases of property, equipment and software (1,764) (3,623) (6,201)
Proceeds from sales of equipment 64 0 0
Net cash provided by (used in) investing activities (80,084) 70,715 (36,609)
Cash flows from financing activities      
Proceeds from issuance of common stock, net of offering costs 616 1,085 117,818
Proceeds from stock option exercises and ESPP purchases 553 574 4,959
Taxes paid related to net share settlement of equity awards (306) 0  
Principal payments on royalty monetization arrangement (157) 0 0
Net proceeds from sale of future royalties 149,655 0 0
Net cash provided by financing activities 150,361 1,659 122,777
Net change in cash and cash equivalents (7,928) (14,585) (57,662)
Cash and cash equivalents at beginning of period 108,884 123,469 181,131
Cash and cash equivalents at end of period 100,956 108,884 123,469
Non-cash operating and investing activities      
Capital Expenditures Incurred but Not yet Paid $ 505 $ 118 $ 508