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Stock-based Compensation - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Oct. 25, 2024 | May 31, 2024 | May 31, 2017 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | May 23, 2024 | May 31, 2023 | May 18, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of offering costs |  |  |  | $ 0 | $ 616 | $ 1,085 |  |  |
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares) |  |  |  | 12,939,517 | 12,223,637 |  |  |  |
Weighted average exercise price (in dollars per share) |  |  |  | $ 14.80 | $ 15.11 |  |  |  |
Accelerated vesting, percentage of unvested awards | 50.00% |  |  |  |  |  |  |  |
Expected dividend yield |  |  |  | 0.00% | 0.00% | 0.00% |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term |  |  |  | 6 years 21 days | 5 years 10 months 17 days | 5 years 11 months 12 days |  |  |
Share-Based Payment Arrangement, Accelerated Cost |  |  |  | $ 6,100 |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected volatility |  |  |  | 95.00% | 76.00% | 88.00% |  |  |
Risk-free interest rate |  |  |  | 3.50% | 3.50% | 1.40% |  |  |
Maximum |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected volatility |  |  |  | 116.00% | 96.00% | 92.00% |  |  |
Risk-free interest rate |  |  |  | 4.70% | 4.80% | 4.00% |  |  |
Dr Scott Koenig |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected dividend yield |  |  |  | 0.00% |  |  |  |  |
Dr Scott Koenig | Minimum |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected volatility |  |  |  | 108.00% |  |  |  |  |
Risk-free interest rate |  |  |  | 4.20% |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term |  |  |  | 1 year |  |  |  |  |
Dr Scott Koenig | Maximum |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected volatility |  |  |  | 174.00% |  |  |  |  |
Risk-free interest rate |  |  |  | 4.30% |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term |  |  |  | 5 years 6 months |  |  |  |  |
Employee Stock |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Offering period |  |  | 6 months |  |  |  |  |  |
Award vesting period |  |  |  | 4 years |  |  |  |  |
Options granted, maximum term |  |  |  | 10 years |  |  |  |  |
Restricted Stock Units |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Outstanding nonvested (in shares) |  |  |  | 1,068,994 | 905,614 |  |  |  |
2016 Employee Stock Purchase Plan |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based compensation, number of shares authorized (in shares) |  |  |  |  |  |  |  |  | 800,000
Maximum employee contribution percent |  |  | 10.00% |  |  |  |  |  |
Percent of fair market value to purchase shares |  |  | 85.00% |  |  |  |  |  |
Common stock purchased by employees (in shares) |  |  |  | 94,619 |  |  |  |  |
Proceeds from issuance of common stock, net of offering costs |  |  |  | $ 300 |  |  |  |  |
StockIncentivePlan2023Member |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based compensation, number of shares authorized (in shares) |  |  |  |  |  |  | 6,850,000 | 4,850,000 |
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares) |  |  |  | 2,326,288 |  |  |  |  |
Weighted average exercise price (in dollars per share) |  |  |  | $ 14.06 |  |  |  |  |
Outstanding nonvested (in shares) |  |  |  | 664,545 |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized |  | 2,000,000 |  |  |  |  |  |  |
Stock Incentive Plan 2013 |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares) |  |  |  | 10,613,229 |  |  |  |  |
Weighted average exercise price (in dollars per share) |  |  |  | $ 14.96 |  |  |  |  |
Outstanding nonvested (in shares) |  |  |  | 404,449 |  |  |  |  |

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