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Commitments and Contingencies (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Mar. 31, 2022
Lessee, Lease, Description [Line Items]        
Right of use asset and lease liability increase $ 3,000      
Weighted average lease term (in years) 10 years 11 years    
Discount rate 12.00% 12.00%    
Operating lease payments $ 3,800 $ 5,900    
Operating lease, ROU Assets 24,509 23,846    
Operating lease cost 6,610 7,459    
Variable lease cost 1,114 1,316    
Sublease Income (1,145) (1,109)    
Lease, cost 6,579 7,666    
2025 5,185      
2026 5,507      
2027 6,258      
2028 7,413      
2029 6,346      
Thereafter 39,773      
Total lease payments 70,482      
Less: imputed interest (33,021)      
Operating lease liabilities 37,461      
Research and development $ 177,194 166,583 $ 207,026  
Minimum        
Lessee, Lease, Description [Line Items]        
Lease renewal term (in years) 5 years      
Synaffix B.V.        
Lessee, Lease, Description [Line Items]        
Potential development and regulatory milestone payments       $ 2,800,000
Research and development $ 4,700 $ 2,800 $ 1,000