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Stock-based Compensation - Option Pricing Assumptions (Details)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend yield	0.00%	0.00%	0.00%
Expected term	6 years 21 days	5 years 10 months 17 days	5 years 11 months 12 days
Dr Scott Koenig
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend yield	0.00%
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	95.00%	76.00%	88.00%
Risk-free interest rate	3.50%	3.50%	1.40%
Minimum | Dr Scott Koenig
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	108.00%
Risk-free interest rate	4.20%
Expected term	1 year
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	116.00%	96.00%	92.00%
Risk-free interest rate	4.70%	4.80%	4.00%
Maximum | Dr Scott Koenig
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	174.00%
Risk-free interest rate	4.30%
Expected term	5 years 6 months

X

- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

+ References

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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