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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Details) - USD ($)
$ in Thousands
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Deferred income tax assets:        
Federal U.S. net operating loss carryforward $ 116,341 $ 140,706    
State net operating loss carryforward 31,758 33,350    
Research and development credit, net 79,108 68,251    
Orphan drug credit, net 33,834 33,330    
Operating lease liabilities 10,308 9,078    
Deferred revenue 18,795 17,442    
Section 174 deferred tax asset 98,810 48,421    
Depreciation 16,272 16,217    
Other 4,971 6,617    
Gross deferred income tax assets 410,197 373,412    
Valuation allowance (401,297) (365,010) $ (372,267) $ (327,592)
Net deferred income tax assets 8,900 8,402    
Deferred income tax liabilities:        
Operating lease ROU assets (6,745) (6,372)    
Prepaid expenditures (2,155) (2,030)    
Gross deferred income tax liabilities (8,900) (8,402)    
Net deferred income tax asset/(liability) $ 0 $ 0