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Income Taxes - Reconciliation of Reported Estimated Income Tax Benefit (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Abstract]
United States federal tax at statutory rate	$ (13,866)	$ (1,902)	$ (25,149)
State taxes (net of federal benefit)	(4,183)	(163)	(7,385)
Deferred income tax adjustments	(7,299)	5,024	308
Deferred state blended rate adjustments	(2,663)	1,841	0
Research credit, net	(12,082)	(3,168)	(4,569)
Orphan drug credit, net	(1,308)	2,374	(10,846)
Other permanent items	388	1,301	1,362
Equity-based compensation	5,594	1,950	1,604
Change in valuation allowance	36,287	(7,257)	44,675
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount	76	0	0
Income tax expense/(benefit)	$ 944	$ 0	$ 0

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