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In-Licensing Arrangement (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
Mar. 31, 2023
In-Licensing arrangement [Line Items]          
Research and development $ 40,791 $ 51,732 $ 80,489 $ 97,760  
Contractual Obligation 4,800   4,800    
Synaffix B.V.          
In-Licensing arrangement [Line Items]          
Potential development and regulatory milestone payments under agreement         $ 2,800,000
Research and development $ 1,200 $ 1,000 $ 2,400 $ 3,400