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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
YearSummary Compensation Table Total for PEO ($) (1)Compensation Actually Paid to PEO ($) (3)Average Summary Compensation Table Total for Non-PEO NEOs ($) (2)Average Compensation Actually Paid to non-PEO NEOs ($) (3)Value of Initial Fixed $100 Investment Based On:
Total Shareholder Return (TSR) ($) (4)		Net Income (Loss) (5)
($ in 000s)
(a)(b)(c)(d)(e)(f)(g)
20246,403,448 1,776,559 2,505,576 1,125,918 14.22 (66,966)
20233,705,825 6,488,555 1,664,706 2,645,829 42.08 (9,058)
20224,627,948 (570,539)1,791,474 100,923 29.35 (119,758)
    
Named Executive Officers, Footnote The dollar amounts reported in column (b) are the amounts of total compensation reported for Scott Koenig, M.D., Ph.D. (our PEO) for each corresponding year in the “Total” column of the Summary Compensation Table ("SCT"). Refer to “Executive Compensation Information—Summary Compensation Table.”The dollar amounts reported in column (d) represent the average of the amounts reported for the Non-PEO NEOs (excluding our PEO) in the “Total” column of the Summary Compensation Table in each applicable year. The Non-PEO NEOs included in the table above were as follows:
•For 2024: James Karrels and Stephen Eck, M.D., Ph.D.
•For 2023: James Karrels and Stephen Eck, M.D., Ph.D.
•For 2022: James Karrels and Eric Risser
    
PEO Total Compensation Amount $ 6,403,448 $ 3,705,825 $ 4,627,948
PEO Actually Paid Compensation Amount $ 1,776,559 6,488,555 (570,539)
Adjustment To PEO Compensation, Footnote The dollar amounts reported in columns (c) and (e) represent the amount of CAP to Dr. Koenig and the average amount of CAP to our non-PEO NEOs, respectively, as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid to our NEOs during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, to calculate CAP, compensation related to equity awards was remeasured based on the following:
•For stock awards to NEOs, the fair values and the change in fair values were determined by the closing pricing of our common stock at each applicable year-end date, or, in the case of vested awards, the actual price on vesting.
•For stock options, a Black-Scholes (“BSM”) option-pricing model was used as of the applicable year-end date, or, in the case of vested options, the vesting date. The BSM model requires us to make assumptions and judgments regarding the variables used in the calculation, including the expected remaining term, expected volatility, and the expected risk-free rate. The valuation assumptions used to calculate the CAP shown in the table were materially consistent with those used to calculate our share-based compensation expense, as disclosed in our 2024 Annual Report on Form 10-K.
The CAP to our PEO and the average CAP to our non-PEO NEOs reflects the following adjustments required by the applicable SEC rules from the total compensation reported in the SCT:

202420232022
PEONon-PEO NEOsPEONon-PEO NEOsPEONon-PEO NEOs
Total Reported in SCT$6,403,448 $2,505,576 $3,705,825 $1,664,706 $4,627,948 $1,791,474 
Less: grant date value of equity awards reported in the SCT(5,313,147)(1,806,206)(2,506,331)(934,629)(3,568,656)(1,152,379)
Year-end fair value of current year equity awards512,785 212,136 4,394,276 1,638,875 1,662,024 535,451 
Year-over-year change in fair value of unvested equity awards(599,348)(131,539)690,071 192,250 (1,907,147)(625,312)
Fair market value of equity awards granted and vested in current year46,825 27,458 406,569 151,467 213,590 68,972 
Change in fair value of equity awards that vested in current year725,996 318,493 (201,855)(66,840)(1,598,298)(517,283)
Compensation Actually Paid$1,776,559 $1,125,918 $6,488,555 $2,645,829 $(570,539)$100,923 
    
Non-PEO NEO Average Total Compensation Amount $ 2,505,576 1,664,706 1,791,474
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,125,918 2,645,829 100,923
Adjustment to Non-PEO NEO Compensation Footnote The dollar amounts reported in columns (c) and (e) represent the amount of CAP to Dr. Koenig and the average amount of CAP to our non-PEO NEOs, respectively, as computed in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid to our NEOs during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, to calculate CAP, compensation related to equity awards was remeasured based on the following:
•For stock awards to NEOs, the fair values and the change in fair values were determined by the closing pricing of our common stock at each applicable year-end date, or, in the case of vested awards, the actual price on vesting.
•For stock options, a Black-Scholes (“BSM”) option-pricing model was used as of the applicable year-end date, or, in the case of vested options, the vesting date. The BSM model requires us to make assumptions and judgments regarding the variables used in the calculation, including the expected remaining term, expected volatility, and the expected risk-free rate. The valuation assumptions used to calculate the CAP shown in the table were materially consistent with those used to calculate our share-based compensation expense, as disclosed in our 2024 Annual Report on Form 10-K.
The CAP to our PEO and the average CAP to our non-PEO NEOs reflects the following adjustments required by the applicable SEC rules from the total compensation reported in the SCT:

202420232022
PEONon-PEO NEOsPEONon-PEO NEOsPEONon-PEO NEOs
Total Reported in SCT$6,403,448 $2,505,576 $3,705,825 $1,664,706 $4,627,948 $1,791,474 
Less: grant date value of equity awards reported in the SCT(5,313,147)(1,806,206)(2,506,331)(934,629)(3,568,656)(1,152,379)
Year-end fair value of current year equity awards512,785 212,136 4,394,276 1,638,875 1,662,024 535,451 
Year-over-year change in fair value of unvested equity awards(599,348)(131,539)690,071 192,250 (1,907,147)(625,312)
Fair market value of equity awards granted and vested in current year46,825 27,458 406,569 151,467 213,590 68,972 
Change in fair value of equity awards that vested in current year725,996 318,493 (201,855)(66,840)(1,598,298)(517,283)
Compensation Actually Paid$1,776,559 $1,125,918 $6,488,555 $2,645,829 $(570,539)$100,923 
    
Compensation Actually Paid vs. Total Shareholder Return
The following graph sets forth the relationship between CAP to our PEO, the average of CAP to our Non-PEO NEOs, and the Company's TSR over the period covering 2022, 2023 and 2024.

5643
    
Total Shareholder Return Amount $ 14.22 42.08 29.35
Net Income (Loss) $ (66,966) (9,058) (119,758)
PEO Name Scott Koenig    
Additional 402(v) Disclosure TSR is determined based on the value of an initial fixed investment of $100 on December 31, 2020. Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between the Company’s share price at the end of the measurement period and the Company’s share price at the beginning of the measurement period.The dollar amounts reported in column (g) represent the amount of net loss reflected in the Company’s audited financial statements for the applicable year.    
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (5,313,147) (2,506,331) (3,568,656)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 512,785 4,394,276 1,662,024
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (599,348) 690,071 (1,907,147)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 46,825 406,569 213,590
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 725,996 (201,855) (1,598,298)
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,806,206) (934,629) (1,152,379)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 212,136 1,638,875 535,451
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (131,539) 192,250 (625,312)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 27,458 151,467 68,972
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 318,493 $ (66,840) $ (517,283)