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Commitments and Contingencies, Type of Agreement (Details) - Maximum [Member] - USD ($) $ in Millions | Dec. 23, 2022 | Jun. 15, 2022 | Nov. 09, 2021 | Apr. 10, 2019 | Jun. 06, 2018
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LCA5/RDH12 Agreement [Member] | Development, Regulatory and Commercial Milestone [Member] |  |  |  |  |
Type of Arrangement [Abstract] |  |  |  |  |
Milestone payments |  | $ 2.6 |  |  |
Iveric Agreement [Member] | Commercial Milestones [Member] | BEST1 Program [Member] |  |  |  |  |
Type of Arrangement [Abstract] |  |  |  |  |
Milestone payments | $ 111.7 |  |  |  |
BEST1 License Agreement [Member] | Commercial Milestones [Member] | First Licensed Product [Member] |  |  |  |  |
Type of Arrangement [Abstract] |  |  |  |  |
Milestone payments |  |  |  | $ 76.4 |
Penn and UF RHO License Agreement [Member] | Development, Regulatory and Commercial Milestone [Member] |  |  |  |  |
Type of Arrangement [Abstract] |  |  |  |  |
Milestone payments |  |  |  |  | $ 93.5
Massachusetts Eye and Ear Infirmary License Agreement [Member] | Development, Regulatory and Commercial Milestone [Member] |  |  |  |  |
Type of Arrangement [Abstract] |  |  |  |  |
Milestone payments |  |  | $ 0.4 |  |

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