    <SEC-DOCUMENT>0001144204-15-000474-index.html : 20150105
    <SEC-HEADER>0001144204-15-000474.hdr.sgml : 20150105
    <ACCEPTANCE-DATETIME>20150105164252
    ACCESSION NUMBER:		0001144204-15-000474
    CONFORMED SUBMISSION TYPE:	424B3
    PUBLIC DOCUMENT COUNT:		9
    FILED AS OF DATE:		20150105
    DATE AS OF CHANGE:		20150105

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			AmpliPhi Biosciences Corp
    		CENTRAL INDEX KEY:			0000921114
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				911549568
    		STATE OF INCORPORATION:			WA
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-193458
    		FILM NUMBER:		15505588

    	BUSINESS ADDRESS:
    		STREET 1:		4870 SADLER ROAD
    		STREET 2:		SUITE 300
    		CITY:			GLEN ALLEN
    		STATE:			VA
    		ZIP:			23060
    		BUSINESS PHONE:		650-888-2422

    	MAIL ADDRESS:
    		STREET 1:		4870 SADLER ROAD
    		STREET 2:		SUITE 300
    		CITY:			GLEN ALLEN
    		STATE:			VA
    		ZIP:			23060

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	TARGETED GENETICS CORP /WA/
    		DATE OF NAME CHANGE:	19940331
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B3
    <SEQUENCE>1
    <FILENAME>v398030_424b3.htm
    <DESCRIPTION>424B3
    <TEXT>
    Document 1 - file: v398030_424b3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>logo_ampliphi-biocorp2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: logo_ampliphi-biocorp2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>spacer.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: spacer.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>line.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: line.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>v367027_img-mice.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: v367027_img-mice.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>v367027_chrt-line.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: v367027_chrt-line.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>v365643_chrt-scatter1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: v365643_chrt-scatter1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>v365643_chrt-scatter2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: v365643_chrt-scatter2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>v365643_img-lifecycle.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: v365643_img-lifecycle.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>