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Stock Incentive Plan Compensation (Tables) | 12 Months Ended
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Dec. 31, 2015
Stock Incentive Plan Compensation [Abstract] |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the stock option grants were as follows:
Allocation of Stock-Based Compensation Expenses | The estimated grant-date fair value of the Company’s stock-based awards is amortized ratably over the awards’ service periods. Stock-based compensation expense recognized was as follows:
|  | Year Ended December 31,
|  | 2015 |  | 2014
Research and development |  | $ | 122,000 |  | $ | 143,000
General and administrative |  |  | 357,000 |  |  | 632,000
Severance charge |  |  | 4,000 |  |  | 1,161,000
Total stock-based compensation expense |  | $ | 483,000 |  | $ | 1,936,000
| (1) | The severance charge component of stock incentive plan compensation relates to accelerated vesting of stock options held by the Company’s former Chief Executive Officer and a former executive per the terms of their employment agreements.
Summary of Stock Option Activity | The following table summarizes stock option activity for the year ended December 31, 2015:
|  |  |  |  | Options Outstanding
|  |  |  |  |  |  |  |  |  | Average |  |  |
|  |  |  |  |  |  |  | Weighted |  | Remaining |  |  |
|  | Shares |  |  |  |  | Average |  | Contractual |  |  |
|  | Available |  |  |  |  | Exercise |  | Term |  | Intrinsic
|  | For Grant |  | Shares |  | Price |  | (Years) |  | Value
Balance, December 31, 2014 |  |  | 785,000 |  |  | 440,695 |  | $ | 9.37 |  |  | 8.18 |  | $ | 640,837
Increase in authorized shares |  |  | 520,000 |  |  | - |  |  | - |  |  | - |  |  | -
Granted |  |  | (596,569) |  |  | 596,569 |  |  | 8.47 |  |  | - |  |  | -
Exercised |  |  | - |  |  | (214,815) |  |  | 8.00 |  |  | - |  |  | (383,994)
Forfeited |  |  | 4,375 |  |  | (4,812) |  |  | 13.64 |  |  | - |  |  | -
Expired |  |  | 10,625 |  |  | (147,868) |  |  | 10.71 |  |  | - |  |  | -
Balance, December 31, 2015 |  |  | 723,431 |  |  | 669,769 |  | $ | 8.68 |  |  | 9.29 |  | $ | -
Vested or expected to vest at December 31, 2015 |  |  |  |  |  | 552,340 |  | $ | 10.03 |  |  | 9.21 |  | $ | -
Exercisable at December 31, 2015 |  |  |  |  |  | 67,084 |  | $ | 10.03 |  |  | 6.71 |  | $ | -
Shares Reserved for Future Issuance | As of December 31, 2015, the Company had reserved shares of its common stock for future issuance as follows:
|  | Shares Reserved
Stock options outstanding |  |  | 669,769
Available for future grants under the Stock Incentive Plan |  |  | 723,431
Warrants |  |  | 1,209,649
Total shares reserved |  |  | 2,602,849

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