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Income Taxes (Components of Deferred Tax Assets) (Details) - USD ($) | Dec. 31, 2015 | Dec. 31, 2014
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Income Taxes [Abstract] |  |
Net operating loss carry-forwards | $ 65,425,000 | $ 61,332,000
Research and orphan drug credit carry-forwards | 5,181,000 | 3,855,000
Depreciation and amortization | (3,000) | (8,000)
Stock options and other | 479,000 | 1,381,000
Intangible Assets | (3,079,000) | (3,155,000)
Deferred Tax Assets, Gross, Total | 68,003,000 | 63,405,000
Valuation allowance for deferred tax assets | (71,008,000) | (66,483,000)
Deferred Tax Assets, Net, Total | $ (3,005,000) | $ (3,078,000)

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