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Warrants (Narrative) (Details) |  |  |  |  | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 03, 2015 USD ($) shares | Apr. 29, 2015 USD ($) shares | Apr. 01, 2015 USD ($) shares | Mar. 16, 2015 USD ($) $ / shares shares | Dec. 31, 2013 $ / shares shares | Jul. 15, 2013 USD ($) $ / shares shares | Mar. 31, 2015 USD ($) | May. 31, 2013 $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) shares | Aug. 02, 2015 shares | May. 08, 2015 USD ($) | Dec. 22, 2011 $ / shares shares
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock, price per share | $ / shares |  |  |  |  |  |  |  |  | $ 3.98 |  |  |  |
Warrant expiration date |  |  |  |  |  |  |  | February through May 2018 |  |  |  |  |
Warrant liability |  |  |  |  |  |  |  |  | $ 6,000 | $ 5,826,000 |  |  |
Amount reclassified from warrant liability into equity | $ 3,281,000 | $ 46,000 | $ 630,000 |  |  |  |  |  |  |  |  | $ 5,462,000 |
Reverse stock split, description | 1-for-50 (1:50) reverse stock split of its common stock, par value $0.01 per share |  |  |  |  |  |  |  |  |  |  |  |
Conversion ratio of reverse stock split | 50 |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized | shares | 670,000,000 |  |  |  |  |  |  |  | 670,000,000 | 670,000,000 | 445,000,000 |  |
Fair value of liquidated damages reclassified to shareholders' equity | $ 120,000 |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on remeasurement of fair value of warrant liability |  |  |  |  |  |  |  |  | $ 610,000 | $ 9,455,000 |  |  |
Warrant issuance expense |  |  |  |  |  |  |  |  | (213,000) |  |  |  |
Series March 2015 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  | 393,939 |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  | $ 10.75 |  |  |  |  |  |  |  |  |
Series B Placement - June 26, 2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant liability |  |  |  |  |  | $ 4,285,000 |  |  |  |  |  |  |
Warrants exercised | shares |  | 4,525 | 52,120 |  |  |  |  |  |  |  |  |  |
Shares issued upon exercise of warrants | shares |  | 4,525 | 52,120 |  |  |  |  |  |  |  |  |  |
Series B Placement - July 15, 2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant liability |  |  |  |  |  | $ 674,000 |  |  |  |  |  |  |
Placement Agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant liability |  |  |  | $ 814,000 |  |  |  |  |  |  |  |  |
Other expenses related to issuance of warrants |  |  |  |  |  |  | $ 213,000 |  | $ 218,000 |  |  |  |
Down Round Position [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  | $ 8.25 |  |  |  |  |  |  |  |  |
Biocontrol Business Combination [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  |  |  |  |  |  |  |  |  |  | 27,103
Exercise price of warrants | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 23.00
Warrant expiration date |  |  |  |  |  |  |  |  | December 2016 |  |  |  |
Convertible Notes Payable [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  |  |  |  |  | 140,608 |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  |  |  |  |  | $ 7.00 |  |  |  |  |
Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock, number of shares issued in transaction | shares |  |  |  | 1,575,758 | 1,440,140 |  |  |  |  |  |  |  |
Sale of stock, price per share | $ / shares |  |  |  | $ 8.25 | $ 12.50 |  |  |  |  |  |  |  |
Warrant liability |  |  |  | $ 4,210,000 |  |  |  |  |  |  |  |  |
Other expenses related to issuance of warrants |  |  |  | $ 213,000 |  |  |  |  |  |  |  |  |
Private Placement [Member] | Series March 2015 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  | $ 10.75 |  |  |  |  |  |  |  |  |
Warrant expiration date |  |  |  | March 2020 |  |  |  |  |  |  |  |  |
Warrant liquidation charges if warrants not exercised according to terms |  |  |  | $ 2,500,000 |  |  |  |  |  |  |  |  |
Warrant liability |  |  |  | $ 3,396,000 |  |  |  |  |  |  |  |  |
Private Placement [Member] | Series December 2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  |  | 86,408 |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  |  | $ 12.50 |  |  |  |  |  |  |  |
Warrant expiration date |  |  |  |  | December 2018 |  |  |  |  |  |  |  |
Private Placement [Member] | Placement Agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  | 94,545 |  |  |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  | $ 10.75 |  |  |  |  |  |  |  |  |
Private Placement - Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants | shares |  |  |  |  |  | 600,805 |  |  |  |  |  |  |
Exercise price of warrants | $ / shares |  |  |  |  |  | $ 7.00 |  |  |  |  |  |  |
Private Placement - Series B Preferred Stock [Member] | Series B Placement - June 26, 2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant expiration date |  |  |  |  |  | June 2018 |  |  |  |  |  |  |
Private Placement - Series B Preferred Stock [Member] | Series B Placement - July 15, 2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant expiration date |  |  |  |  |  | July 2018 |  |  |  |  |  |  |
Private Placement - Series B Preferred Stock [Member] | Placement Agent [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant issuance expense |  |  |  |  |  | $ 759,000 |  |  |  |  |  |  |

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