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Stockholders' Equity (Deficit) (Details) - USD ($) |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Nov. 22, 2016 | Jun. 03, 2016 | Mar. 16, 2015 | May 31, 2016 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015
Class of Stock [Line Items] |  |  |  |  |  |  |
Sale of stock, price per share |  |  |  |  |  | $ 0.44 |
Proceeds from equity offerings, gross | $ 4,000,000 | $ 5,000,000 |  |  |  |  |
Exercise price of warrants | $ 0.75 |  |  |  |  | $ 2.29 | $ 8.19
Proceeds from equity offerings, net |  |  |  |  |  | $ 7,566,000 | $ 12,384,000
Value of common stock issued |  |  |  |  |  | 1,545,000 |
Costs directly allocable to offering |  |  |  |  |  | (756,000) | (213,000)
Series March 2015 Warrants [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Number of securities called by warrants |  |  | 393,939 |  |  |  |
Exercise price of warrants |  |  | $ 10.75 |  |  |  |
Private Placement [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Sale of stock, number of shares sold in transaction |  |  | 1,575,758 |  |  |  |
Sale of stock, price per share |  |  | $ 8.25 |  |  |  |
Proceeds from issuance of private placement, gross |  |  | $ 13,000,000 |  |  |  |
Warrant liability |  |  | $ 4,200,000 |  |  |  |
Private Placement [Member] | Placement Agent [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Number of securities called by warrants |  |  | 94,545 |  |  |  |
Exercise price of warrants |  |  | $ 10.75 |  |  |  |
Fees paid to placement agent |  |  | $ 800,000 |  |  |  |
Other expenses related to issuance of warrants |  |  |  |  | $ 200,000 |  | 200,000
Private Placement [Member] | Series March 2015 Warrants [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Decrease to additional paid-in capital resulting from warrants issued |  |  |  |  |  |  | $ 4,000,000
Securities Purchase Agreement [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Sale of stock, number of shares sold in transaction |  |  |  | 2,127,660 |  |  |
Number of securities called by warrants |  |  |  | 1,063,830 |  |  |
Number of shares called by each warrant |  |  |  | 0.50 |  |  |
Sale of stock, price per share |  |  |  | $ 2.35 |  |  |
Proceeds from equity offerings, gross |  |  |  | $ 5,000,000 |  |  |
Exercise price of warrants |  |  |  | $ 2.25 |  |  |
Expiration term of warrants (in years) |  |  |  | 5 years |  |  |
Proceeds from equity offerings, net |  |  |  | $ 4,200,000 |  |  |
Placement agent fee as percentage of total gross proceeds of offering |  |  |  | 7.00% |  |  |
Fees paid to placement agent |  |  |  | $ 75,000 |  |  |
Derivative liability |  |  |  | $ 1,800,000 |  |  |
Dividend yield |  |  |  | 0.00% |  |  |
Volatility |  |  |  | 123.00% |  |  |
Risk-free interest rate |  |  |  | 1.23% |  |  |
Value of common stock issued |  |  |  | $ 3,200,000 |  |  |
Costs directly allocable to offering |  |  |  | 800,000 |  |  |
Payments of stock issuance costs allocable to warrants |  |  |  | $ 200,000 |  |  |
Changes in estimated fair value |  |  |  |  |  | (1,500,000) |
Public Offering of Warrants and Common Stock [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Sale of stock, number of shares sold in transaction | 5,335,000 |  |  |  |  |  |
Number of securities called by warrants | 5,335,000 |  |  |  |  |  |
Sale of stock, price per share | $ 0.75 |  |  |  |  |  |
Proceeds from equity offerings, gross | $ 4,000,000 |  |  |  |  |  |
Exercise price of warrants | $ 0.75 |  |  |  |  |  |
Expiration term of warrants (in years) | 5 years |  |  |  |  |  |
Proceeds from equity offerings, net | $ 3,700,000 |  |  |  |  |  |
Placement agent fee as percentage of total gross proceeds of offering | 6.00% |  |  |  |  |  |
Fees paid to placement agent | $ 70,000 |  |  |  |  |  |
Derivative liability | 2,900,000 |  |  |  |  |  |
Value of common stock issued | 1,100,000 |  |  |  |  |  |
Costs directly allocable to offering | 700,000 |  |  |  |  |  |
Payments of stock issuance costs allocable to warrants | $ 300,000 |  |  |  |  |  |
Changes in estimated fair value |  |  |  |  |  | $ (886,000) |

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