    <SEC-DOCUMENT>0001144204-18-053841-index.html : 20181015
    <SEC-HEADER>0001144204-18-053841.hdr.sgml : 20181015
    <ACCEPTANCE-DATETIME>20181015164417
    ACCESSION NUMBER:		0001144204-18-053841
    CONFORMED SUBMISSION TYPE:	424B4
    PUBLIC DOCUMENT COUNT:		7
    FILED AS OF DATE:		20181015
    DATE AS OF CHANGE:		20181015

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			AmpliPhi Biosciences Corp
    		CENTRAL INDEX KEY:			0000921114
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				911549568
    		STATE OF INCORPORATION:			WA
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B4
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-226959
    		FILM NUMBER:		181122643

    	BUSINESS ADDRESS:
    		STREET 1:		3579 VALLEY CENTRE DRIVE
    		CITY:			SAN DIEGO
    		STATE:			CA
    		ZIP:			92130
    		BUSINESS PHONE:		804-827-2524

    	MAIL ADDRESS:
    		STREET 1:		3579 VALLEY CENTRE DRIVE
    		CITY:			SAN DIEGO
    		STATE:			CA
    		ZIP:			92130

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	TARGETED GENETICS CORP /WA/
    		DATE OF NAME CHANGE:	19940331
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B4
    <SEQUENCE>1
    <FILENAME>tv504787-424b4.htm
    <DESCRIPTION>PROSPECTUS
    <TEXT>
    Document 1 - file: tv504787-424b4.htm

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    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_ampliphi.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_ampliphi.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>tv501500_slide1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: tv501500_slide1.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tv501500_slide2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tv501500_slide2.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tv501500_slide3.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tv501500_slide3.jpg

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    <SEQUENCE>6
    <FILENAME>tv501500_slide4.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: tv501500_slide4.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>tv501500_slide5.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: tv501500_slide5.jpg

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