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Segment Reporting - Segment information (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment Reporting |  |  |  |
Grant and award revenue | $ 1,159 | $ 2,973 | $ 3,819 | $ 3,939
Total research and development expenses | 5,824 | 9,485 | 17,647 | 25,975
Total general and administrative expenses | 3,111 | 3,244 | 8,983 | 9,861
Total operating expenses | 8,935 | 12,729 | 26,630 | 35,836
Operating loss | (7,776) | (9,756) | (22,811) | (31,897)
Other income (expense), net | (18,899) | 4,275 | (26,690) | 10,381
Net loss | (26,675) | (5,481) | (49,501) | (21,516)
Single Reportable Segment |  |  |  |
Segment Reporting |  |  |  |
Grant and award revenue | 1,159 | 2,973 | 3,819 | 3,939
Expenses not allocated by projects | 545 | 726 | 1,657 | 1,903
Total external research and development expenses | 1,139 | 4,202 | 3,653 | 10,357
Research and development personnel expenses | 2,287 | 2,874 | 6,893 | 8,296
Other research and development expenses | 2,398 | 2,409 | 7,101 | 7,322
Total research and development expenses | 5,824 | 9,485 | 17,647 | 25,975
General and administrative personnel expenses | 1,141 | 1,273 | 3,733 | 3,778
Other general and administrative expenses | 1,970 | 1,971 | 5,250 | 6,083
Total general and administrative expenses | 3,111 | 3,244 | 8,983 | 9,861
Total operating expenses | 8,935 | 12,729 | 26,630 | 35,836
Operating loss | (7,776) | (9,756) | (22,811) | (31,897)
Other income (expense), net | (18,899) | 4,275 | (26,690) | 10,381
Net loss | (26,675) | (5,481) | (49,501) | (21,516)
Single Reportable Segment | AP-PA02: Non-Cystic Fibrosis Bronchiectasis |  |  |  |
Segment Reporting |  |  |  |
External research and development expenses | 190 | 1,858 | (98) | 5,459
Single Reportable Segment | AP-PA02: Cystic Fibrosis |  |  |  |
Segment Reporting |  |  |  |
External research and development expenses |  |  | 25 | 235
Single Reportable Segment | AP-SA02: Bacteremia |  |  |  |
Segment Reporting |  |  |  |
External research and development expenses | $ 404 | $ 1,618 | 2,067 | 2,752
Single Reportable Segment | AP-SA02Prosthetic Joint Infection |  |  |  |
Segment Reporting |  |  |  |
External research and development expenses |  |  | $ 2 | $ 8

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