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Segment Reporting - Segment information (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Segment Reporting        
Grant and award revenue $ 1,159 $ 2,973 $ 3,819 $ 3,939
Total research and development expenses 5,824 9,485 17,647 25,975
Total general and administrative expenses 3,111 3,244 8,983 9,861
Total operating expenses 8,935 12,729 26,630 35,836
Operating loss (7,776) (9,756) (22,811) (31,897)
Other income (expense), net (18,899) 4,275 (26,690) 10,381
Net loss (26,675) (5,481) (49,501) (21,516)
Single Reportable Segment        
Segment Reporting        
Grant and award revenue 1,159 2,973 3,819 3,939
Expenses not allocated by projects 545 726 1,657 1,903
Total external research and development expenses 1,139 4,202 3,653 10,357
Research and development personnel expenses 2,287 2,874 6,893 8,296
Other research and development expenses 2,398 2,409 7,101 7,322
Total research and development expenses 5,824 9,485 17,647 25,975
General and administrative personnel expenses 1,141 1,273 3,733 3,778
Other general and administrative expenses 1,970 1,971 5,250 6,083
Total general and administrative expenses 3,111 3,244 8,983 9,861
Total operating expenses 8,935 12,729 26,630 35,836
Operating loss (7,776) (9,756) (22,811) (31,897)
Other income (expense), net (18,899) 4,275 (26,690) 10,381
Net loss (26,675) (5,481) (49,501) (21,516)
Single Reportable Segment | AP-PA02: Non-Cystic Fibrosis Bronchiectasis        
Segment Reporting        
External research and development expenses 190 1,858 (98) 5,459
Single Reportable Segment | AP-PA02: Cystic Fibrosis        
Segment Reporting        
External research and development expenses     25 235
Single Reportable Segment | AP-SA02: Bacteremia        
Segment Reporting        
External research and development expenses $ 404 $ 1,618 2,067 2,752
Single Reportable Segment | AP-SA02Prosthetic Joint Infection        
Segment Reporting        
External research and development expenses     $ 2 $ 8