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Stockholders' Equity - Schedule of Stock Based Compensation (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016
Share-based Compensation Expense | $ 435,679 | $ 935,899
General and Administrative [Member] |  |
Share-based Compensation Expense | 408,772 | 873,392
Research and Development [Member] |  |
Share-based Compensation Expense | $ 26,907 | $ 62,507

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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