<SEC-DOCUMENT>0001808805-22-000041-index.html : 20220428
<SEC-HEADER>0001808805-22-000041.hdr.sgml : 20220428
<ACCEPTANCE-DATETIME>20220428160333
ACCESSION NUMBER:		0001808805-22-000041
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20220614
FILED AS OF DATE:		20220428
DATE AS OF CHANGE:		20220428

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Nautilus Biotechnology, Inc.
		CENTRAL INDEX KEY:			0001808805
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39434
		FILM NUMBER:		22866406

	BUSINESS ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102
		BUSINESS PHONE:		206-333-2001

	MAIL ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARYA Sciences Acquisition Corp III
		DATE OF NAME CHANGE:	20200408
</SEC-HEADER>
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<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>nautilusdef14a20220614a.htm
<DESCRIPTION>DEF 14A
<TEXT>
Document 1 - file: nautilusdef14a20220614a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>nautilus_primarylogoxbluea.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: nautilus_primarylogoxbluea.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>proxycard001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: proxycard001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>proxycard002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: proxycard002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>sujalsignaturea.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: sujalsignaturea.jpg

</DOCUMENT>
</SEC-DOCUMENT>