<SEC-DOCUMENT>0001808805-22-000085-index.html : 20220802
<SEC-HEADER>0001808805-22-000085.hdr.sgml : 20220802
<ACCEPTANCE-DATETIME>20220802162813
ACCESSION NUMBER:		0001808805-22-000085
CONFORMED SUBMISSION TYPE:	POS AM
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20220802
DATE AS OF CHANGE:		20220802

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Nautilus Biotechnology, Inc.
		CENTRAL INDEX KEY:			0001808805
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		POS AM
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-258100
		FILM NUMBER:		221129095

	BUSINESS ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102
		BUSINESS PHONE:		206-333-2001

	MAIL ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARYA Sciences Acquisition Corp III
		DATE OF NAME CHANGE:	20200408
</SEC-HEADER>
<DOCUMENT>
<TYPE>POS AM
<SEQUENCE>1
<FILENAME>nautilus-posamsx1tosx3.htm
<DESCRIPTION>POS AM
<TEXT>
Document 1 - file: nautilus-posamsx1tosx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>2
<FILENAME>exhibit231consentofpwcllp.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 2 - file: exhibit231consentofpwcllp.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.2
<SEQUENCE>3
<FILENAME>exhibit242powerofattorney.htm
<DESCRIPTION>EX-24.2
<TEXT>
Document 3 - file: exhibit242powerofattorney.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>nautilus_primarylogoxblue.jpg
<TEXT>
Document 4 - file: nautilus_primarylogoxblue.jpg

</DOCUMENT>
</SEC-DOCUMENT>