<SEC-DOCUMENT>0001628280-24-007392-index.html : 20240228
<SEC-HEADER>0001628280-24-007392.hdr.sgml : 20240228
<ACCEPTANCE-DATETIME>20240228072519
ACCESSION NUMBER:		0001628280-24-007392
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		9
FILED AS OF DATE:		20240228
DATE AS OF CHANGE:		20240228

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Nautilus Biotechnology, Inc.
		CENTRAL INDEX KEY:			0001808805
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				981541723
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-277437
		FILM NUMBER:		24690165

	BUSINESS ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102
		BUSINESS PHONE:		206-333-2001

	MAIL ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARYA Sciences Acquisition Corp III
		DATE OF NAME CHANGE:	20200408
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>nautilusbiotechnology-sx3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: nautilusbiotechnology-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>2
<FILENAME>exhibit107-sx3.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 2 - file: exhibit107-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>3
<FILENAME>exhibit12-sx3.htm
<DESCRIPTION>EX-1.2
<TEXT>
Document 3 - file: exhibit12-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>4
<FILENAME>exhibit44-sx3.htm
<DESCRIPTION>EX-4.4
<TEXT>
Document 4 - file: exhibit44-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>5
<FILENAME>exhibit51-sx3.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 5 - file: exhibit51-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>6
<FILENAME>exhibit231-sx3.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 6 - file: exhibit231-sx3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>nautilus_primarylogoxblue.jpg
<TEXT>
Document 7 - file: nautilus_primarylogoxblue.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>nautiluslogoa.jpg
<TEXT>
Document 8 - file: nautiluslogoa.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>picture1.jpg
<TEXT>
Document 9 - file: picture1.jpg

</DOCUMENT>
</SEC-DOCUMENT>