<SEC-DOCUMENT>0001808805-25-000023-index.html : 20250304
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<ACCEPTANCE-DATETIME>20250304165215
ACCESSION NUMBER:		0001808805-25-000023
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20250303
FILED AS OF DATE:		20250304
DATE AS OF CHANGE:		20250304

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Weld Gwen E
		CENTRAL INDEX KEY:			0001378831
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39434
		FILM NUMBER:		25705703

	MAIL ADDRESS:	
		STREET 1:		C/O ISILON SYSTEMS, INC.
		STREET 2:		3101 WESTERN AVENUE
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Nautilus Biotechnology, Inc.
		CENTRAL INDEX KEY:			0001808805
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				981541723
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102
		BUSINESS PHONE:		206-333-2001

	MAIL ADDRESS:	
		STREET 1:		2701 EASTLAKE AVE EAST
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARYA Sciences Acquisition Corp III
		DATE OF NAME CHANGE:	20200408
</SEC-HEADER>
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<SEQUENCE>1
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<DESCRIPTION>FORM 4
<TEXT>
Document 1 - file: wk-form4_1741125127.html

Document 1 - RAW XML: wk-form4_1741125127.xml

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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>nautilusbiotechnology-se.htm
<DESCRIPTION>EX-24
<TEXT>
Document 2 - file: nautilusbiotechnology-se.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>nautilusbiotechnology-se001.jpg
<TEXT>
Document 3 - file: nautilusbiotechnology-se001.jpg

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<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>nautilusbiotechnology-se002.jpg
<TEXT>
Document 4 - file: nautilusbiotechnology-se002.jpg

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