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Equity Incentive Plans and Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2025
Share-Based Payment Arrangement [Abstract] |
Schedule of Significant Assumptions | The significant assumptions used in these calculations are summarized as follows:
| Year Ended December 31, 2025 |  | Year Ended December 31, 2024 |  |
Expected term (in years) | 5.3 - 6.0 |  | 5.3 - 6.1 |  |
Expected volatility | 97.5% - 103.9% |  | 99.7% - 101.6% |  |
Expected dividend rate | 0.0% |  | 0.0% |  |
Risk free interest rate | 3.6% - 4.0% |  | 3.4% - 4.6% |  |
Schedule of Option Award Activity | The following table summarizes option award activity during the year ended December 31, 2025:
| Number of Stock Option Awards |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Life (Years) |  | Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2024 | 16,634,775 |  |  | $ | 3.57 |  |  |  |  |
Granted | 3,659,200 |  |  | $ | 1.01 |  |  |  |  |
Exercised | (112,085) |  |  | $ | 0.52 |  |  |  |  |
Forfeited | (2,911,020) |  |  | $ | 2.59 |  |  |  |  |
Outstanding as of December 31, 2025 | 17,270,870 |  |  | $ | 3.22 |  |  | 6.9 |  | $ | 5,696 |
Options vested and expected to vest as of December 31, 2025 | 17,270,870 |  |  | $ | 3.22 |  |  |  |  |
Vested and exercisable at December 31, 2025 | 11,281,386 |  |  | $ | 4.00 |  |  | 5.9 |  | $ | 2,581 |
Schedule of Stock Based Compensation Expense | The following sets forth the total stock-based compensation expense for the Company’s stock options and ESPP included in the Company’s consolidated statements of operations:
(in thousands) | Year Ended December 31, 2025 |  | Year Ended December 31, 2024 |  |
Research and development | $ | 2,690 |  |  | $ | 4,626 |  |  |
General and administrative | 4,154 |  |  | 8,075 |  |  |
Total stock-based compensation expense | $ | 6,844 |  |  | $ | 12,701 |  |  |

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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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