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Equity Incentive Plans and Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Significant Assumptions

The significant assumptions used in these calculations are summarized as follows:

			Year Ended December 31, 2025						Year Ended December 31, 2024
Expected term (in years)			5.3 - 6.0						5.3 - 6.1
Expected volatility			97.5% - 103.9%						99.7% - 101.6%
Expected dividend rate			0.0%						0.0%
Risk free interest rate			3.6% - 4.0%						3.4% - 4.6%

Schedule of Option Award Activity

The following table summarizes option award activity during the year ended December 31, 2025:

			Number of Stock Option Awards						Weighted Average Exercise Price						Weighted Average Remaining Contractual Life (Years)						Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2024			16,634,775						$	3.57
Granted			3,659,200						$	1.01
Exercised			(112,085)						$	0.52
Forfeited			(2,911,020)						$	2.59
Outstanding as of December 31, 2025			17,270,870						$	3.22					6.9						$	5,696
Options vested and expected to vest as of December 31, 2025			17,270,870						$	3.22
Vested and exercisable at December 31, 2025			11,281,386						$	4.00					5.9						$	2,581

Schedule of Stock Based Compensation Expense

The following sets forth the total stock-based compensation expense for the Company’s stock options and ESPP included in the Company’s consolidated statements of operations:

(in thousands)			Year Ended December 31, 2025						Year Ended December 31, 2024
Research and development			$	2,690					$	4,626
General and administrative			4,154						8,075
Total stock-based compensation expense			$	6,844					$	12,701

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Tabular disclosure of the change in stock options.

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