    <SEC-DOCUMENT>0001808805-26-000025-index.html : 20260428
    <SEC-HEADER>0001808805-26-000025.hdr.sgml : 20260428
    <ACCEPTANCE-DATETIME>20260428161053
    ACCESSION NUMBER:		0001808805-26-000025
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260428
    DATE AS OF CHANGE:		20260428
    EFFECTIVENESS DATE:		20260428

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Nautilus Biotechnology, Inc.
    		CENTRAL INDEX KEY:			0001808805
    		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		EIN:				981541723
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39434
    		FILM NUMBER:		26907833

    	BUSINESS ADDRESS:
    		STREET 1:		2701 EASTLAKE AVE EAST
    		CITY:			SEATTLE
    		STATE:			WA
    		ZIP:			98102
    		BUSINESS PHONE:		206-333-2001

    	MAIL ADDRESS:
    		STREET 1:		2701 EASTLAKE AVE EAST
    		CITY:			SEATTLE
    		STATE:			WA
    		ZIP:			98102

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ARYA Sciences Acquisition Corp III
    		DATE OF NAME CHANGE:	20200408
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>nautilus2025annualreport.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: nautilus2025annualreport.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>